Artificial intelligence (AI) is currently considered a disruptive key technology in the field of biomedical engineering. However, there is more to it than just the applications, advantages and challenges of AI in this field. The book takes a closer look at various additional aspects and provides a more comprehensive view of AI in healthcare. The first part provides introductory considerations from a historical, technical, socio-scientific, legal and ethical perspectives. Complementing this, the second part illustrates these topics using various applications in the field of biomedical engineering. These cannot be covered exhaustively, but a broad overview is provided and the relevant challenges are addressed. Finally, the last part deals with questions relating to the framework conditions, the regulation of AI and the associated business models. Last but not least, brief introductory statements from the Federal Ministry of Research, Technology and Space and the DGBMT on the topic of AI in biotechnology and healthcare underscore the relevance of the contributions.